pendred's syndrome revisited

pendred's syndrome is defined as a triad of congenital perceptive hearing loss, goiter, and abnormal perchlorate test. three brothers with pendred's syndrome [p.s.] are reported. the oldest brother has hearing loss (he has been deaf and mute since childhood) and has a large goiter. a thyroid scan revealed euthyroid multinodular goiter and a perchlorate test was performed, and reported abnormal. his brother had the same manifestations but with less severity and after subtotal thyroidectomy, the pathology report revealed follicular carcinoma. the youngest brother had hearing loss since childhood but a normal sized thyroid. we report three patients and compare the frequency of their symptoms with that reported in the literature.